Porous magnetic nanomaterials and nanocomposites for biomedical application

This is a a multidisciplinary project for the development of a number of monodispersed, biocompatible and superparamagnetic porous nanoparticles with high surface area and various surface functionalisations suitable for the use in biological (in vitro and in vivo) experiments.

Water dispersible magnetite nanoparticles have been synthesized by thermal decomposition method and with a wet technique by forming a micro-emulsion solution and the surface of the nanoparticles has been functionalised by different functional groups such as thiol, amino acid, etc as per specific requirements. Special designed gold-coated magnetic nanoparticles have been prepared for site-specific exosome profiling for the use in cancer diagnostics.

Selected publications:

1. Nanoarchitectured peroxidase-mimetic nanozymes
2. Superparamagnetic nanoarchitectures for disease-specific biomarker detection
3. DC and AC magnetic fields increase neurite outgrowth of SH-SY5Y neuroblastoma cells with and without retinoic acid
4. Enhanced Peroxidase Mimetic Activity of Porous Iron Oxide Nanoflakes

Collaboration:

• Dr Shiddiky, Griffith University
• A/Prof Konstantinov Kosta, University of Wollongong
• Prof Boris Martinac, Victor Chang Cardiac Research Institute